Aeronautics

7

Piasecki Aircraft

Reviving the former Sikorsky plant to build a zero-emission hydrogen helicopter.

Rotorcraft R&DCoatesville

Leading Edge Composites

Aerospace-grade composite parts and tooling for Boeing, Sikorsky, Lockheed, and the military.

Aerospace compositesCoatesville

Ansys Government Initiatives (AGI)

The Exton-born maker of STK, the software behind U.S. space and defense missions.

Space & defense softwareExton

Innovative Aerosystems (IS&S)

Publicly traded avionics maker building flight-deck systems for commercial and military aircraft.

AvionicsExton

SureFlight

On-airport shop for aircraft paint, interiors, and avionics completions.

Aircraft MROCoatesville

Chester County Aviation

The county airport's flight school, maintenance shop, charter operator, and Robinson dealer.

Flight training & serviceCoatesville

Brandywine Photonics

Builds hyperspectral and EO/IR imaging payloads for defense, weather, and satellites.

Defense & space opticsExton

Technology

12

Bentley Systems

NASDAQ-listed software that engineers the world's roads, bridges, rail, and power grids.

Infrastructure softwareExton

QVC Group

The video-commerce company behind QVC and HSN, headquartered at West Chester's Studio Park.

Commerce mediaWest Chester

CTDI

A global telecom engineering and repair company that started in a West Chester garage.

Telecom engineeringWest Chester

Vishay Intertechnology

One of the world's largest makers of semiconductors and electronic components.

SemiconductorsMalvern

Cantaloupe

Payments and software powering self-service commerce — vending, micro-markets, EV charging.

Fintech · paymentsMalvern

Rajant Corporation

Inventor of “Kinetic Mesh” mobile wireless networks used in mining, defense, and ports.

Wireless networkingMalvern

iPipeline

Cloud software that digitizes how life insurance is sold and processed.

Insurance SaaSExton

Frontline Education

K-12 administration software used by thousands of U.S. school districts.

Education technologyMalvern

Ricoh USA

The Americas headquarters of Ricoh, delivering imaging, IT, and digital-workplace services.

IT & workplace servicesExton

Daniel H. Wagner Associates

Applied-math firm whose search software helped find a lost H-bomb and the USS Scorpion.

Defense softwareExton

Vanguard

One of the world's largest asset managers, and the county's biggest employer and tech workforce.

Finance with major tech operationsMalvern

Anovaa

Digital loan-origination platform for banks, credit unions, and specialty lenders.

Lending SaaSMalvern

Life Sciences

25

West Pharmaceutical Services

S&P 500 maker of the components that hold and deliver the world's injectable medicines.

Drug deliveryExton

Teleflex

S&P 500 maker of single-use medical devices for critical care and surgery.

Medical devicesTredyffrin (Wayne)

Endo

Specialty-pharma maker of XIAFLEX, based at a large Malvern campus.

Specialty pharmaceuticalsMalvern

Neuronetics

Maker of NeuroStar, the leading TMS system for treatment-resistant depression.

NeuromodulationMalvern

Philips / BioTelemetry

The cardiac-monitoring pioneer founded as CardioNet, now Philips' Malvern hub.

Cardiac diagnosticsMalvern

Frontage Laboratories

Global drug-development contract lab, headquartered in Exton.

Contract research (CRDMO)Exton

Siemens Healthineers (US)

The U.S. base of Siemens Healthineers, rooted in Malvern since 2000.

Medical imaging & health ITMalvern

Trevena

Biopharma behind OLINVYK for acute pain, built on Nobel-winning receptor science.

BiopharmaceuticalChesterbrook

Aclaris Therapeutics

Clinical-stage biopharma developing immunology and inflammation therapies.

BiopharmaceuticalChesterbrook

DePuy Synthes (J&J)

Johnson & Johnson's orthopedics, trauma, and spine business, with a major West Chester campus.

Orthopedic devicesWest Chester

Ocugen

Clinical-stage biotech developing gene therapies for inherited blindness.

Gene therapyMalvern

Annovis Bio

Phase 3 biopharma developing an oral therapy for Alzheimer's and Parkinson's.

Neurodegeneration biopharmaMalvern

Verrica Pharmaceuticals

Dermatology company behind YCANTH, the first FDA-approved treatment for molluscum.

Dermatology biopharmaWest Chester

Castle Creek Biosciences

Develops personalized gene therapies for rare genetic diseases, with in-house manufacturing.

Cell & gene therapyExton

Virpax Pharmaceuticals

Developing proprietary drug-delivery systems for non-opioid pain management.

Non-opioid painBerwyn

TELA Bio

Regenerative medical devices for hernia repair and breast reconstruction.

Soft-tissue devicesMalvern

Trice Medical

Maker of the mi-eye needle arthroscope for in-office joint diagnosis.

Imaging devicesMalvern

Centinel Spine

Global leader in total disc replacement via its prodisc platform.

Spinal implantsWest Chester

LifeScan

Maker of the OneTouch blood-glucose systems used by over 20 million people.

Diabetes diagnosticsMalvern

Fujirebio Diagnostics

US base of a world leader in tumor-marker immunoassays.

In-vitro diagnosticsMalvern

Pharmaron Exton

Nonclinical CRO specializing in DMPK and cell & gene therapy analytics.

Contract research (CRO)Exton

Charles River Laboratories

Biologics testing and manufacturing sites for the drug-development industry.

Biologics CROMalvern

Catalent Micron

Contract micronization and particle engineering to improve drug bioavailability.

Particle-engineering CDMOMalvern

Chiral Technologies

North American arm of Daicel's chiral separation science.

Chiral chromatographyWest Chester

Teva (Cephalon campus)

Teva's North America R&D campus, built on the former Cephalon operations.

Pharma R&DWest Chester

Advanced Manufacturing

12

AMETEK

S&P 500 maker of electronic instruments and electromechanical devices.

Electronic instrumentsBerwyn

Saint-Gobain / CertainTeed

North American HQ of the global materials giant and its CertainTeed brand.

Building materialsMalvern

Johnson Matthey

US precious-metals and catalyst production for the British specialty-chemicals firm.

Catalysts & fine chemicalsWest Chester

Sartomer (Arkema)

Global HQ of Arkema's reactive resins for coatings, electronics, and 3D printing.

Specialty materialsExton

Silicon Power

Maker of high-power thyristors and power-conversion systems for grid and defense.

Power semiconductorsMalvern

Bender

North American HQ for the world leader in ground-fault monitoring.

Electrical-safety devicesExton

ifm efector

US headquarters of the German industrial-automation sensor group.

Automation sensorsMalvern

Cleveland-Cliffs Coatesville

America's oldest steel mill, operating on the Brandywine since 1810.

SteelmakingCoatesville

CNC Manufacturing

Precision machine shop for dental, defense, and aerospace parts.

Precision machiningCoatesville

Weston Solutions

Employee-owned environmental and infrastructure engineering firm.

Environmental engineeringWest Chester

Advanced GeoServices

Civil, geotechnical, and environmental engineering firm.

Civil & geotechnical engineeringWest Chester

Dansko

The comfort-footwear brand known for its clogs, a certified B Corp.

FootwearWest Grove

Food & Agriculture

6

Herr Foods

The largest family-owned salty-snack maker in the United States.

Snack foodsNottingham

Victory Brewing

A pioneering Pennsylvania craft brewery, home of HopDevil and Golden Monkey.

Craft beerDowningtown

Phillips Mushroom Farms

The largest grower of specialty mushrooms in the United States.

Specialty mushroomsKennett Square

South Mill Champs

One of North America's largest vertically integrated mushroom producers.

Mushroom productionKennett Square

To-Jo Mushrooms

Fourth-generation family mushroom grower and processor.

MushroomsAvondale

Mother Earth Organic Mushrooms

A century-old family farm and certified-organic mushroom grower.

Organic mushroomsLandenberg